https://www.ticrobioservices.com/ticro-bioservices daily 1.0 2025-07-18 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/e46c29f4-75aa-4403-a46f-83a1071c00fc/parasite.jpg TICRO Bioservices, The Preclinical Infectious Disease CRO - Make it stand out Injections & Surgery Our in vivo models facilitate the study of the pathogenesis and complications of infectious disease, and permit preclinical evaluations of treatment protocols as a precursor to clinical studies. https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/1f35414e-9ac5-49c9-96e6-56fb2c77978c/bacteria-staph-aureus.jpg TICRO Bioservices, The Preclinical Infectious Disease CRO - Make it stand out Diagnostic Assays TICRO boasts qualified, highly trained personnel combined with access to state-of-the-art facilities, including Immunohistochemistry, Flow Cytometry, Microscopy and Imaging and Molecular Biology Core Facilities, to meticulously conduct experiments and assays according to study specifications. https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/1713cd4d-afa8-4e01-83c5-dba6ad63c4eb/influenza-virus.jpg TICRO Bioservices, The Preclinical Infectious Disease CRO Infectious Disease Models Infectious diseases remain a leading cause of morbidity and mortality worldwide. In vivo mouse models facilitate evaluation of the effectiveness of vaccines and/or therapeutic regimens as well as their potential to alter immune cell responses to infection. https://www.ticrobioservices.com/about-us daily 0.75 2023-04-26 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/fe8fbdd9-f668-4c62-af4e-84cfc15b5bf9/SARS-CoV-2-virus-particles.jpg About Us - Make it stand out Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles (orange), isolated from a patient. https://www.ticrobioservices.com/preclinical-services-overview daily 0.75 2022-04-26 https://www.ticrobioservices.com/preclinical-services/infectious-disease-models daily 0.75 2025-08-20 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/2edf1dcc-d0b0-4ab9-9d54-1f55b727567c/SARS-CoV-2-Viral-Dosing-Study-Average-Weight-Loss.png Infectious Disease Models Kinetics of SARS-CoV-2 infection in transgenic mice expressing human ACE2. K18-hACE2 mice were intranasally infected with escalating doses of SARS-CoV-2 strain USA/WA1/2020 and monitored for daily weight loss and observed for morbidity and mortality. Please use the Contact Us form to inquire on data obtained using additional variants of concern (VOC). https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/81cbe438-5eb8-4189-a53e-842b5d66c7f1/SARS-CoV-2-Viral-Dosing-Study-Survival-Data.png Infectious Disease Models Kinetics of SARS-CoV-2 infection in transgenic mice expressing human ACE2. K18-hACE2 mice were intranasally infected with escalating doses of SARS-CoV-2 strain USA/WA1/2020 and monitored for daily weight loss and observed for morbidity and mortality. Please use the Contact Us form to inquire on data obtained using additional variants of concern (VOC). https://www.ticrobioservices.com/preclinical-services/diagnostic-assays daily 0.75 2022-05-03 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/0c3d0720-8d63-4e0d-ad58-b4f06268a3f3/diagnostic-assays-image-ELISPOT.png Diagnostic Assays - Make it stand out Image of a diagnostic assay ELISPOT https://www.ticrobioservices.com/preclinical-services/injections-surgery daily 0.75 2022-05-11 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/3a3a0ec0-0ed8-4053-873e-36d51c7acb22/CD45-1-blue-CD45-2+green-CD4-red-Mtb-antigen-white-image.jpg Injections & Surgery - Make it stand out Confocal image of adoptively transferred effector CD4 + T cells (CD4+ CD45.1+ (yellow); CD4+CD45.2+ (magenta)) in mouse lung following M. tuberculosis infection. M. tuberculosis antigen (white) located within the lung. https://www.ticrobioservices.com/core-facilities-overview daily 0.75 2022-04-25 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/aa27e431-5f1e-4f2d-af76-6d15be6113eb/ticro-bio-trudeau-institute-facilities.jpg Core Facilities Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.ticrobioservices.com/core-facilities/animal-facilities daily 0.75 2022-04-28 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/819cf0fa-a2b8-4d04-8038-ccaa3dd5b2fd/b6-mouse.jpg Animal Facilities - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.ticrobioservices.com/core-facilities/imaging-histology daily 0.75 2024-03-20 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/a891390b-c23e-443b-a158-999e34734b19/macs-in-airways-rotation.gif Imaging & Histology 3D confocal microscope image of macrophages (red) in the mouse lung airways (green). Image courtesy of Trudeau Institute Imaging & Histology Core Facility https://www.ticrobioservices.com/core-facilities/flow-cytometry daily 0.75 2022-04-25 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/b17f600c-e2a9-448a-8b05-f7745ba647b4/dna-stain.png Flow Cytometry DNA Stain https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/d50de5ba-1338-4957-af60-7a608a0ab057/Comp-APC-Cv7-A.png Flow Cytometry Comp-APC-Cv7-A https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/cfcd2947-b8d0-474c-ae13-cdacf71a08f8/CD4+BV421.png Flow Cytometry CD4 BV421 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/ce255a21-b62c-4b0d-b1df-7a847291588f/tSNE+of+Single+Cells+1.png Flow Cytometry tSNE of Single Cells 1 https://www.ticrobioservices.com/preclinical-services/treatments-drug-dosing daily 0.75 2022-04-11 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/d345a6ae-5818-4d6a-bb4f-7b5570a39143/influenza-virus-survival-data-only.jpg Treatments & Drug Dosing B6 mice were either immunized with an influenza vaccine or left untreated (PBS control). Data show weight loss and survival curves from vaccinated and control mice following intranasal challenge with infectious influenza virus. https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/e1c9213c-c43b-4ede-a393-757ae6a64cc0/influenza-virus-survival-with-model.jpg Treatments & Drug Dosing B6 mice were either immunized with an influenza vaccine or left untreated (PBS control). Data show weight loss and survival curves from vaccinated and control mice following intranasal challenge with infectious influenza virus. https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/84c88e8f-6e48-4497-af6d-b127040f0778/influenza-virus-weight-loss-data-only.jpg Treatments & Drug Dosing B6 mice were either immunized with an influenza vaccine or left untreated (PBS control). Data show weight loss and survival curves from vaccinated and control mice following intranasal challenge with infectious influenza virus. https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/99844090-f78a-4c8a-a5df-51cff3969e3d/influenza-virus-weight-loss-data-with-model.jpg Treatments & Drug Dosing B6 mice were either immunized with an influenza vaccine or left untreated (PBS control). Data show weight loss and survival curves from vaccinated and control mice following intranasal challenge with infectious influenza virus. https://www.ticrobioservices.com/news/publications daily 0.75 2024-10-08 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/71f1b360-02e0-47bd-b649-209cdae854a4/SARs-CoV-2+Variants Publications - Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations Abstract: Prevention of viral escape and increased coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal antibodies (mAbs) targeting multiple sites of vulnerability on the coronavirus spike glycoprotein. Here we identify several potent neutralizing antibodies directed against either the N-terminal domain (NTD) or the receptor-binding domain (RBD) of the spike protein. Administered in combinations, these mAbs provided low-dose protection against SARS-CoV-2 infection in the K18-human angiotensin-converting enzyme 2 mouse model, using both neutralization and Fc effector antibody functions. The RBD mAb WRAIR-2125, which targets residue F486 through a unique heavy-chain and light-chain pairing, demonstrated potent neutralizing activity against all major SARS-CoV-2 variants of concern. In combination with NTD and other RBD mAbs, WRAIR-2125 also prevented viral escape. These data demonstrate that NTD/RBD mAb combinations confer potent protection, likely leveraging complementary mechanisms of viral inactivation and clearance. https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/220f6c9d-67e2-4e03-9992-a99ba8fe0c08/ferritin-nanoparticle.jpg Publications - SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity Abstract: The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the long-term threat of emerging coronaviruses. Here, we design and characterize four categories of engineered nanoparticle immunogens that recapitulate the structural and antigenic properties of the prefusion SARS-CoV-2 spike (S), S1, and receptor-binding domain (RBD). These immunogens induce robust S binding, ACE2 inhibition, and authentic and pseudovirus neutralizing antibodies against SARS-CoV-2. A spike-ferritin nanoparticle (SpFN) vaccine elicits neutralizing titers (ID50 > 10,000) following a single immunization, whereas RBD-ferritin nanoparticle (RFN) immunogens elicit similar responses after two immunizations and also show durable and potent neutralization against circulating VoCs. Passive transfer of immunoglobulin G (IgG) purified from SpFN- or RFN-immunized mice protects K18-hACE2 transgenic mice from a lethal SARS-CoV-2 challenge. Furthermore, S-domain nanoparticle immunization elicits ACE2-blocking activity and ID50 neutralizing antibody titers >2,000 against SARS-CoV-1, highlighting the broad response elicited by these immunogens. https://www.ticrobioservices.com/contact-us daily 0.75 2022-04-28 https://www.ticrobioservices.com/privacy-policy daily 0.75 2022-04-27 https://www.ticrobioservices.com/frequently-asked-questions daily 0.75 2022-04-07 https://www.ticrobioservices.com/preclinical-services/biospecimen-collection daily 0.75 2022-04-29 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/993d0dcb-1c36-4e4e-ad59-d43eefaad467/Murine+Brain+tissue.png Biospecimen Collection Murine Brain Tissue https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/047c9d41-cea0-426a-ae2c-5c5b176665ef/Murine+Skin+tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/4507b57c-df70-4763-adc7-a9192df97963/Murine+Splenic+tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/d0770291-4f43-44a0-96c6-145aa0c461bd/Murine+Thymic+tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/30077ffd-0913-4e31-81fd-e28e47f23c45/Murine+Muscle+tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/f93e168a-b220-466c-9d44-0dace3501868/Murine+Cardiac+tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/c48e25dd-ea30-4a57-9f3a-aa67d590b2a8/Murine+Bone+and+Marrow+tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/31bc29b4-6d1a-425d-a5a4-65372434e1c5/Murine+Lung+Tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/0820e3d3-0d8a-4775-9117-100f879f3da0/Murine+Small+Intestine.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/166a20cf-8f75-4ecf-ac62-e33c735b250d/Murine+Liver+Tissue.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/29f5468b-4e93-49c8-bbbf-8e471389ebb7/Murine+Liver+Tissue+II.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/07bb8c98-4ee4-4c65-be57-d69d56b89a89/Murine+Embryo+and+Placenta.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/ca9167d3-e53b-4a1a-9902-bd4994d38e31/Gall+Bladder.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/e4c7babd-8210-4742-be34-629174109b80/Placenta.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/64e834fe-be34-471b-8952-a11ac6fffcbc/Mouse+Tail+cross+section.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/d3fc483b-5b82-4b4f-be5e-1bcd497e7008/Mouse+Knee+-+Frontal+Plane.png Biospecimen Collection https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/610f27f7-ac1a-46cc-b054-f6f665a832e3/Mouse+Knee+-+Sagittal+Plane.png Biospecimen Collection https://www.ticrobioservices.com/careers daily 0.75 2023-07-24 https://www.ticrobioservices.com/core-facilities/immunohistochemistry daily 0.75 2024-03-20 https://images.squarespace-cdn.com/content/v1/6220dbe465071807b433c949/35ef1d05-030f-42c4-b621-71860dfaa26d/tb-infected-foamy-macrophages.jpg Immunohistochemistry Fluorescent microscope image of foamy macrophages infected with Mycobacterium tuberculosis (red) with visible lipid vesicles (green). Cell nuclei (blue) are stained with Hoechst dye. Image courtesy of Trudeau Institute Imaging & Histology Core Facility